Guest Current Subscriptions | Open Access Plus | Free Content | About | Sign in | New Users: Sign up | Mark List  
  Letters in Drug Design & Discovery

Volume 8 Issue 5
ISSN: 1570-1808

 
   All Titles

Synthesis and Antimicrobial Activity of 8-Alkylpalmatine Derivatives
pp.464-468 (5) Authors: Teng-Wen Ma, Xiao-Li Ye, Xue-Gang Li, Bao-Shun Zhang, Xiao-Fei Jiang, Zu Chen
 
Abstract:

The compounds 8-butyl(2),8-hexyl-(3),8-octyl-(4),8-decyl(5),8-dodecyl(6) and 8-hexadecyl(7) palmatine derivatives were synthesized and confirmed by UV, IR, CHN, 1H NMR, 13C NMR and MS spectra data. The series of the synthesized compounds has been tested for their antimicrobial activity in vitro to evaluate structure-activity relationships. Substitution of the H with alkyl groups at C-8-H led to significant changes in the antimicrobial activity. The antimicrobial activity of the substituted derivatives was up to 64 times higher than that of palmatine, especially against Gram-positive bacteria. Which increased as the aliphatic chain was elongated and then decreased gradually when the alkyl chain exceeded eight carbon atoms. 8-Octylpalmatin-e (4) displayed the highest antimicrobial activity of all compounds. The LD50 values of compounds (2-7) decreased as the aliphatic chain was elongated. Compound 7 showed the lowest toxicity.

Keywords: 8-alkylpalmatine derivatives, Antimicrobial activity, Palmatine, Structure-activity relationships, Synthesis, Toxicity, pharmacological, hypoglycemic, antiarrhythmic, antioxidant, 13-alkyl-substitution, microorganisms, Mass spectrometry
Affiliation: Chemistry Institute of Pharmaceutical Resources, School of Pharmaceutical Science, Southwest University, Chongqing 400715, People's Republic of China.

  Key: New Content Free Content Open Access Plus Subscribed Content

Bentham Science Publishers
www.benthamscience.com

  Copyright © 1994 - 2014   Bentham Science Publishers