Guest Current Subscriptions | Open Access Plus | Free Content | About | Sign in | New Users: Sign up | Mark List  
  Inflammation & Allergy-Drug Targets (Formerly Current Drug Targets - Inflammation & Allergy)

Volume 10 Issue 3
ISSN: 1871-5281

 
   All Titles

Interleukin-25 Negatively Controls Pathogenic Responses in the Gut
pp.187-191 (5) Authors: Eleonora Franze, Angelamaria Rizzo, Roberta Caruso, Francesco Pallone, Giovanni Monteleone
 
Abstract:

Although interleukin-25 (IL-25) has been traditionally considered as a cytokine involved in T helper (Th) 2 cell-associated allergic diseases and host defence against helminthic parasites, recent studies have shown that IL-25 exerts negative effects on the initiation and progression of Th1/Th17-mediated pathologies. This later function of IL-25 is particularly evident at the gut level, where IL-25 could contribute to attenuate tissue-damaging immune responses. These new and exciting pre-clinical observations suggest that therapeutic interventions aimed at enhancing IL-25 activity could be useful in the management of patients with chronic gut inflammation.

Keywords: IL-25, IBD, Th1, Th17, TNF-, IFN-, NK cells, gut, gut immune, cytokines
Affiliation: Dipartimento di Medicina Interna, Universita Tor Vergata, Via Montpellier, 1, 00133 Roma, Italy.

  Key: New Content Free Content Open Access Plus Subscribed Content

Bentham Science Publishers
www.benthamscience.com

  Copyright © 1994 - 2014   Bentham Science Publishers