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  Current Angiogenesis

Volume 1 Issue 1
ISSN: 2211-5528

 
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Antibiotics Delay Wound Healing: an Effect Reversed by Co-Administering TLR 7 and 9 Ligands
pp.46-51 (6) Authors: Hiroyasu Ito, Noriho Iida, Dennis M. Klinman
   
Abstract:

Pathogenic bacteria are recognized by cells expressing Toll-like receptors (TLRs). This interaction initiates an innate immune response that increases host resistance to infection and accelerates wound healing. This work examines whether antibiotics that eliminate bacteria have a detrimental effect on the rate of wound repair. Results indicate that antibiotic treatment i) eliminates bacteria from the skin, ii) reduces wound inflammation (as manifest by decreased expression of IL-1β, CCL2, IFNα and IFNβ mRNA) and thereby iii) delays wound healing. This adverse consequence is corrected by co-administering the TLR9 ligand CpG ODN and/or the TLR7 ligand imiquimod.

Keywords: CpG oligonucleotide, imiquimod, PAMP, TLR, wound healing, Antibiotics, TLR 7, Ligands, TLR 9
Affiliation: Bldg 567, Rm 205, NCI in Frederick, Frederick, MD 21702, United States.

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