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  Current Medicinal Chemistry

Volume 19 Issue 22
ISSN: 0929-8673

 
   All Titles

Approaches to Target Profiling of Natural Products
pp.3841-3855 (15) Authors: R. Yue, L. Shan, X. Yang, W. Zhang
 
Abstract:

Natural products have long been regarded as excellent sources for drug discovery given their structural diversity and wide variety of biological activities. Accordingly, the identification of the molecular targets of natural products is an important aspect of current drug discovery, as knowledge regarding a compound's molecular targets will greatly aid drug development and design. In this review, we will explore genomic, proteomic, and computational approaches to the elucidation of these mechanisms and the implications of these approaches for the target profiling of natural products. The recent applications of target profiling of natural products will also be reviewed.

Keywords: Natural products, target profiling, genomics, proteomics, affinity chromatography, molecular docking, pharmacophore, chemobioinformatics, system biological network analysis, mechanism of action
Affiliation: Department of Medicinal Chemistry of Natural products, School of Pharmacy, Second Military Medical University, 325 Guo- He Road, Shanghai 200433, P.R. China.

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