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Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Volume 8 Issue 7
ISSN: 1871-5206
eISSN: 1875-5992

 

   All Titles

  Targeting RSK: An Overview of Small Molecule Inhibitors
  pp.710-716 (7) Author: Tam Luong Nguyen
 
 
      Abstract

Ribosomal S6 kinase (RSK) is a family of serine/threonine kinases that has been identified as a promising anti-cancer target. While a number of protein kinase inhibitors that have potent activity against other serine/threonine kinases were shown to also inactivate RSK, there is keen interest in the three different inhibitor chemotypes that were shown to be RSK specific, since these compounds have tremendous utility as chemical probes in elucidating the biochemistry of the RSK signaling cascade and unraveling the molecular basis of cancer. Because each compound may have therapeutic potential, the nonspecific kinase inhibitors as well as the RSK specific inhibitors will be discussed.

 
  Keywords: Serine/threonine kinase, inhibitor, RSK specific
  Affiliation: Target Structure-based Drug Discovery Group, SAIC-Frederick, Inc., National Cancer Institute Frederick, Frederick, MD 21702, USA.
 
  Key: New Content Free Content Open Access Plus Subscribed Content

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