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Anti-Infective Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Anti-Infective Agents)

Volume 6 Issue 1
ISSN: 1871-5214
eISSN: 2211-3533


   All Titles

  Mechanism of Action and Potential for Use of Tea Catechin as an Antiinfective Agent
  pp.57-62 (6) Authors: Tadakatsu Shimamura, Wei-Hua Zhao, Zhi-Qing Hu

“Drinking several cups of green tea a day keeps the doctor away” is clearly an overstatement. However, extensive research has revealed that the predominant catechin from tea (Camellia sinensis), epigallocatechin gallate (EGCg), has significant medicinal and health-promoting properties. This review summarizes what is presently known about the antimicrobial properties of EGCg, with a particular focus on the synergistic relationship between EGCg and β-lactams in the inhibition of methicillin-resistant Staphylococcus aureus (MRSA). The mechanisms of action and prospects for use of tea catechins such as EGCg as an anti-infective agent are discussed.

  Keywords: Tea, catechins, EGCg, polyphenols, flavanols, antimicrobial agents, β-lactams, MRSA
  Affiliation: Department of Microbiology and Immunology, Showa University School of Medicine, 1-5-8 Hatanodai,Shinagawa-ku, Tokyo 142-8555, Japan.
  Key: New Content Free Content Open Access Plus Subscribed Content

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