Vaccinium is a genus of shrubs several of which, including cranberry, lingonberry, and blueberry, produce edible fruit. Consumption of the fruit of these plants and juices pressed from it has long been known to have healthful effects. A number of functional compounds have been extracted from the fruits and seeds of these plants. Anthocyanidins and related compounds have been reported to possess antimicrobial, antioxidant, and anti-inflammatory properties. Extracts of the fruits have been applied to the inhibition of non-enzymatic glycosylation in anti-aging preparations. The oil of the cranberry seed is high in antioxidants and is a source of omega-3, -6, and -9 fatty acids making it an attractive cosmetics component. The inhibition of tumor growth, angiogenesis, and metastasis by extracts of these fruits has been described. Extracts of the plants have also been applied to the development of antimicrobial paints and coatings. Here, we provide an overview of the wide range of applications described for various compounds from and preparations of these plants and survey the recent patents related to those applications.