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Current Angiogenesis

Volume 1 Issue 2
ISSN: 2211-5528
eISSN: 2211-5536


   All Titles

  Neuropilin Signalling in Vascular Development and Pathology
  pp.125-132 (8) Authors: Alessandro Fantin, Alice Plein, Christiana Ruhrberg
doi: 10.2174/2211552811201020125

The creation of functional blood vessel circuits is a critical step during embryonic development to support organ growth and differentiation. In the adult, angiogenesis occurs naturally in the female reproductive system, during exercise- induced muscle growth and in wound healing. However, adult angiogenesis also promotes tumour growth and contributes to many other diseases with tissue ischemia. The transmembrane protein neuropilin 1 (NRP1) is an isoformselective receptor for the most potent vascular growth and permeability factor, VEGF-A. NRP1 also functions as a receptor for an archetypical neural guidance cue called SEMA3A that inhibits tumour angiogenesis. In the adult vasculature, both VEGF-A and SEMA3A increase vascular permeability and thereby promote the formation of tissue oedema. Here, we review current knowledge about NRP1 function during blood vessel growth and vascular pathology.

  Keywords: Angiogenesis, VEGF, VEGF-A, SEMA3A, neuropilin, VEGFR2, endothelial cells, Neuropilin Signalling, Vascular Development, Pathology
  Affiliation: UCL Institute of Ophthalmology, University College London, 11-43 Bath Street, London EC1V 9EL, UK.
  Key: New Content Free Content Open Access Plus Subscribed Content

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