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Current Angiogenesis

Volume 1 Issue 4
ISSN: 2211-5528
eISSN: 2211-5536

 

   All Titles

  Anti-Angiogenic Treatment for Exudative Age-Related Macular Degeneration: New Strategies are Underway
  pp.318-334 (17) Author: Patrycja Nowak-Sliwinska
doi: 10.2174/2211552811201040318
 
 
      Abstract

Exudative age-related macular degeneration (AMD) is the leading cause of blindness in elderly people in the western world. Recent developments in the field yielded vascular endothelial growth factor (VEGF) targeted strategies that caused a revolution in the treatment of AMD. Although the therapy of the disease has dramatically improved, the treatment depends on repetitive and invasive intravitreal injections of neutralizing antibodies or antibody-based constructs that have the risk of side effects and are still a major burden for the patient. Learning from the field of oncology, it is clear that new therapeutic opportunities for AMD are finding their way into the clinic. The rapidly developing market of new angiostatic agents will allow better treatments for exudative AMD in the near future. This review summarizes the opportunities and challenges of this field of research.

 
  Keywords: Exudative age-related macular degeneration, anti-angiogenesis, combination treatment, endothelium, gene therapy, photodynamic therapy, tyrosine kinase inhibitors, vascular endothelial growth factor
  Affiliation: Patrycja Nowak-Sliwinska, University Hospital (CHUV), Lausanne, CH-1011, Switzerland.
 
  Key: New Content Free Content Open Access Plus Subscribed Content

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