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Current Alzheimer Research

Volume 6 Issue 3
ISSN: 1567-2050
eISSN: 1875-5828

 

   All Titles

  Towards Retinoid Therapy for Alzheimer's Disease
  pp.302-311 (10) Authors: K. Shudo, H. Fukasawa, M. Nakagomi, N. Yamagata
 
 
      Abstract

Alzheimer's disease(AD) is associated with a variety of pathophysiological features, including amyloid plaques, inflammation, immunological changes, cell death and regeneration processes, altered neurotransmission, and agerelated changes. Retinoic acid receptors (RARs) and retinoids are relevant to all of these. Here we review the pathology, pharmacology, and biochemistry of AD in relation to RARs and retinoids, and we suggest that retinoids are candidate drugs for treatment of AD.

 
  Keywords: Alzheimer's disease, retinoid, retinoic acid receptors, inflammation, immunology, regulatory T cell, neurodegeneration
  Affiliation: Research Foundation ITSUU Laboratory, 2-28-10 tamagawa, setagaya-ku, Tokyo 158-0094, Japan.
 
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