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Current Alzheimer Research

Volume 8 Issue 3
ISSN: 1567-2050
eISSN: 1875-5828

 

   All Titles

  Frontotemporal Dementia Caused by CHMP2B Mutations
  pp.246-251 (6) Authors: A. M. Isaacs, P. Johannsen, I. Holm, J. E. Nielsen, FReJA Consortium
 
 
      Abstract

CHMP2B mutations are a rare cause of autosomal dominant frontotemporal dementia (FTD). The best studied example is frontotemporal dementia linked to chromosome 3 (FTD-3) which occurs in a large Danish family, with a further CHMP2B mutation identified in an unrelated Belgian familial FTD patient. These mutations lead to C-terminal truncations of the CHMP2B protein and we will review recent advances in our understanding of the molecular effects of these mutant truncated proteins on vesicular fusion events within the endosome-lysosome and autophagy degradation pathways. We will also review the clinical features of FTD caused by CHMP2B truncation mutations as well as new brain imaging and neuropathological findings. Finally, we collate the current data on CHMP2B missense mutations, which have been reported in FTD and motor neuron disease.

 
  Keywords: Frontotemporal dementia, CHMP2B, endosome, lysosome, autophagy, brain imaging, neuropathology, CBD, FTLD-TDP, CHMP2BIntron5, CHMP2BDelta10, CHMP2BQ165X, lateral preponderance, MND, neurotransmitter receptors
  Affiliation: Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London,WC1N 3BG, UK.
 
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