Guest Open Access Plus | Free Content | About | Sign in | New Users: Sign up | Mark List  

Current Alzheimer Research

Volume 9 Issue 5
ISSN: 1567-2050
eISSN: 1875-5828

 

   All Titles

  Alzheimer's Disease and Environmental Exposure to Lead: The Epidemiologic Evidence and Potential Role of Epigenetics
  pp.563-573 (11) Authors: Kelly M. Bakulski, Laura S. Rozek, Dana C. Dolinoy, Henry L. Paulson, Howard Hu
 
 
      Abstract

Several lines of evidence indicate that the etiology of late-onset Alzheimer's disease (LOAD) is complex, with significant contributions from both genes and environmental factors. Recent research suggests the importance of epigenetic mechanisms in defining the relationship between environmental exposures and LOAD. In epidemiologic studies of adults, cumulative lifetime lead (Pb) exposure has been associated with accelerated declines in cognition. In addition, research in animal models suggests a causal association between Pb exposure during early life, epigenetics, and LOAD. There are multiple challenges to human epidemiologic research evaluating the relationship between epigenetics, LOAD, and Pb exposure. Epidemiologic studies are not well-suited to accommodate the long latency period between exposures during early life and onset of Alzheimer's disease. There is also a lack of validated circulating epigenetics biomarkers and retrospective biomarkers of Pb exposure. Members of our research group have shown bone Pb is an accurate measurement of historical Pb exposure in adults, offering an avenue for future epidemiologic studies. However, this would not address the risk of LOAD attributable to early-life Pb exposures. Future studies that use a cohort design to measure both Pb exposure and validated epigenetic biomarkers of LOAD will be useful to clarify this important relationship.

 
  Keywords: DNA methylation, epigenetics, epidemiology, Late-onset Alzheimer's disease, lead exposure, Pb, Pb exposure, Anthropometric measures
  Affiliation: 6667 SPH Tower, 1415 Washington Heights, Ann Arbor, MI 48109-2029, USA.
 
  Key: New Content Free Content Open Access Plus Subscribed Content

Bentham Science Publishers
www.benthamscience.com

 

  Copyright © 1994 - 2014   Bentham Science Publishers