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Current Biotechnology

Volume 1 Issue 3
ISSN: 2211-5501
eISSN: 2211-551X


   All Titles

  Biotransformation of (-)-α-Santonin by Aspergillus parasiticus and Antimicrobial Efficacy of the Transformed Products
  pp.194-198 (5) Authors: Busi Siddhardha, Ramakrishna Gadupudi, Mandava Venkata Basaveswara Rao
doi: 10.2174/2211550111201030194

Biotransformation of (-)-α-santonin using Aspergillus parasiticus resulted in the production of 3,4-epoxy-α-santonin, 4,5-dihydro-α-santonin and 1,2-dihydro-α-santonin and 3 minor products and the biological activity of the transformed products was established by antibacterial & antifungal assays. 3,4-epoxy-α-santonin exhibited higher degree of antibacterial and antifungal activity. 4,5-dihydro-α-santonin showed slight increase in the activity, compared to (-)-α-Santonin. 1,2-dihydro-α-santonin is equipotent to the substrate ( (-)-α-Santonin ). This is the first report on the Biotransformation of (-)-α-Santonin by Aspergillus parasiticus and evaluation of the biological activities of the biotransformed products.

  Keywords: (-)-α-santonin, biotransformation, Aspergillus parasiticus, 3, 4-epoxy-α-santonin, 4, 5-dihydro-α-santonin, 1, 2-dihydro-α-santonin, antibacterial, Cytotoxic activity, regioselectivity, stereoselectivity, anti-HIV, Spectrometry, NMR Spectrum, Antibacterial Activity, Antifungal Activity
  Affiliation: Department of Biochemistry and Molecular Biology, Pondicherry University, Puducherry - 605014, India.
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