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Current Drug Targets

Volume 7 Issue 11
ISSN: 1389-4501
eISSN: 1873-5592


   All Titles

  GSK3 at the Edge: Regulation of Developmental Specification and Cell Polarization
  pp.1411-1419 (9) Authors: Leung Kim, Alan R. Kimmel

GSK3 is a multifunctional protein kinase that is pivotal for the regulation of metabolism, the cytoskeleton, and gene expression. Multicellular eukaryotes utilize GSK3 as a molecular switch to specify distinct cell fates, but also to organize these cells spatially within the developing organism. We discuss the central role of GSK3 in control of the Wnt, Hedgehog, cAMP (in Dictyostelium), and other signaling pathways, but also focus on significant new evidence that GSK3 is required to establish cell polarity.

  Keywords: Wnt, Frizzled, Hedgehog, Presenilin, PAR, Cell Motility, Chemotaxis, Dictyostelium
  Affiliation: Laboratory of Cellular and Developmental Biology, NIDDK, National Institutes of Health, Bethesda,MD 20892-8028, USA.
  Key: New Content Free Content Open Access Plus Subscribed Content

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