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Current Drug Targets

Volume 13 Issue 1
ISSN: 1389-4501
eISSN: 1873-5592

 

   All Titles

  Protein-Protein Interactions at the Adrenergic Receptors
  pp.15-27 (13) Authors: Susanna Cotecchia, Laura Stanasila, Dario Diviani
   
      Abstract

The adrenergic receptors are among the best characterized G protein-coupled receptors (GPCRs) and knowledge on this receptor family has provided several important paradigms about GPCR function and regulation. One of the most recent paradigms initially supported by studies on adrenergic receptors is that both βarrestins and G proteincoupled receptors themselves can act as scaffolds binding a variety of proteins and this can result in growing complexity of the receptor-mediated cellular effects. In this review we will briefly summarize the main features of βarrestin binding to the adrenergic receptor subtypes and we will review more in detail the main proteins found to selectively interact with distinct AR subtype. At the end, we will review the main findings on oligomerization of the AR subtypes.

 
  Keywords: adrenergic receptor subtypes, signaling complexes, arrestins, receptor, oligomerization, protein-protein interactions, catecholamines, G protein coupled receptors, GPCR, beta-AR, receptor oligomerization
  Affiliation: Department de Pharmacologie et de Toxicologie, Universite de Lausanne, Switzerland.
 
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