Guest Open Access Plus | Free Content | About | Sign in | New Users: Sign up | Mark List  

Current Genomics

Volume 12 Issue 5
ISSN: 1389-2029
eISSN: 1875-5488

 

   All Titles

  Shaping the Genome with Non-Coding RNAs
  pp.307-321 (15) Authors: Xue Q.D. Wang, Jennifer L. Crutchley, Josee Dostie
 
 
      Abstract

The human genome must be tightly packaged in order to fit inside the nucleus of a cell. Genome organization is functional rather than random, which allows for the proper execution of gene expression programs and other biological processes. Recently, three-dimensional chromatin organization has emerged as an important transcriptional control mechanism. For example, enhancers were shown to regulate target genes by physically interacting with them regardless of their linear distance and even if located on different chromosomes. These chromatin contacts can be measured with the “chromosome conformation capture” (3C) technology and other 3C-related techniques. Given the recent innovation of 3C-derived approaches, it is not surprising that we still know very little about the structure of our genome at highresolution. Even less well understood is whether there exist distinct types of chromatin contacts and importantly, what regulates them. A new form of regulation involving the expression of long non-coding RNAs (lncRNAs) was recently identified. lncRNAs are a very abundant class of non-coding RNAs that are often expressed in a tissue-specific manner. Although their different subcellular localizations point to their involvement in numerous cellular processes, it is clear that lncRNAs play an important role in regulating gene expression. How they control transcription however is mostly unknown. In this review, we provide an overview of known lncRNA transcription regulation activities. We also discuss potential mechanisms by which ncRNAs might exert three-dimensional transcriptional control and what recent studies have revealed about their role in shaping our genome.

 
  Keywords: Chromatin, epigenetics, gene regulation, non-coding RNA, polycomb repression complex, ribonucleoprotein complex, transcription, tiRNAs, HOX genes, Xist
  Affiliation: Department of Biochemistry, and Goodman Cancer Research Center, McGill University, 3655 Promenade Sir-William-Osler, Room 815A, Montreal, Quebec, H3G1Y6, Canada.
 
  Key: New Content Free Content Open Access Plus Subscribed Content

Bentham Science Publishers
www.benthamscience.com

 

  Copyright © 1994 - 2014   Bentham Science Publishers