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Current Genomics

Volume 13 Issue 2
ISSN: 1389-2029
eISSN: 1875-5488

 

   All Titles

  Current Applications of Models of Genetic Effects with Interactions Across the Genome
  pp.163-175 (13) Author: Jose M. Alvarez-Castro
 
 
      Abstract

Models of genetic effects integrate the action of genes, regulatory regions and interactions among alleles across the genome. Such theoretical frameworks are critical for applied studies in at least two ways. First, discovering genetic networks with specific effects underlying traits in populations requires the development of models that implement those effects as parameters–adjusting the implementation of epistasis parameters in genetic models has for instance been a requirement for properly testing for epistasis in gene-mapping studies. Second, studying the properties and implications of models of genetic effects that involve complex genetic networks has proven to be valuable, whether those networks have been revealed for particular organisms or inferred to be of interest from theoretical works and simulations. Here I review the current state of development and recent applications of models of genetic effects. I focus on general models aiming to depict complex genotype-to-phenotype maps and on applications of them to networks of interacting loci.

 
  Keywords: Epistasis, Functional models, Genetic networks, Models of genetic effects, Quantitative trait loci, Statistical models, Genetic Filtering, Multilinear Epistasis, Matrix notation, Multiple alleles
  Affiliation: University of Santiago de Compostela, Department of Genetics, Veterinary Faculty, Avda. Carvalho Calero, ES-27002 Lugo, Galiza, Spain.
 
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