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Current Gene Therapy

Volume 7 Issue 3
ISSN: 1566-5232
eISSN: 1875-5631

 

   All Titles

  Current Advances and Future Challenges in Adenoviral Vector Biology and Targeting
  pp.189-204 (16) Authors: Samuel K. Campos, Michael A. Barry
 
 
      Abstract

Gene delivery vectors based on Adenoviral (Ad) vectors have enormous potential for the treatment of both hereditary and acquired disease. Detailed structural analysis of the Ad virion, combined with functional studies has broadened our knowledge of the structure/function relationships between Ad vectors and host cells/tissues and substantial achievement has been made towards a thorough understanding of the biology of Ad vectors. The widespread use of Ad vectors for clinical gene therapy is compromised by their inherent immunogenicity. The generation of safer and more effective Ad vectors, targeted to the site of disease, has therefore become a great ambition in the field of Ad vector development. This review provides a synopsis of the structure/function relationships between Ad vectors and host systems and summarizes the many innovative approaches towards achieving Ad vector targeting.

 
  Keywords: Ad biology, Ad trafficking, Ad structure
  Affiliation: Department of Internal Medicine,Department of Immunology, Division of Infectious Diseases, Translational Immunovirology Program, Molecular Medicine Program, Mayo Clinic, Rochester, MN 55902, USA.
 
  Key: New Content Free Content Open Access Plus Subscribed Content

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