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Current Immunology Reviews

Volume 6 Issue 1
ISSN: 1573-3955
eISSN: 1875-631X

 

   All Titles

  Microencapsulation of Vaccine Antigens and Adjuvants for Mucosal Targeting
  pp.29-37 (9) Authors: Thejani E. Rajapaksa, David D. Lo
   
      Abstract

Delivery of vaccine antigens that can trigger potent mucosal immune response is one of the effective strategies to overcome a wide array of infectious diseases. Microencapsulation of vaccine antigens with Poly(lactide-co-glycolic acids) (PLGA), an FDA approved biodegradable polymer, has been investigated for targeted M-cell uptake. While PLGA possesses many attractive properties, a successful PLGA based mucosal-targeted vaccine has yet to be introduced. This review focuses on the physiochemical properties important in the preparation of antigen-loaded PLGA microparticles, properties that influence M-cell specific uptake, and the induction of effective immune responses. In addition, a possible role of microparticle properties in immune adjuvant activity is discussed. A careful consideration of these factors may yet lead to the development of an effective needle-free mucosal vaccine using polymer microparticles.

 
  Keywords: M-cell targeting, PLGA, microparticles
  Affiliation: Division of Biomedical Sciences, University of California, Riverside, CA 92521, USA.
 
  Key: New Content Free Content Open Access Plus Subscribed Content

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