Guest Open Access Plus | Free Content | About | Sign in | New Users: Sign up | Mark List  

Current Immunology Reviews

Volume 6 Issue 1
ISSN: 1573-3955
eISSN: 1875-631X


   All Titles

  Microencapsulation of Vaccine Antigens and Adjuvants for Mucosal Targeting
  pp.29-37 (9) Authors: Thejani E. Rajapaksa, David D. Lo

Delivery of vaccine antigens that can trigger potent mucosal immune response is one of the effective strategies to overcome a wide array of infectious diseases. Microencapsulation of vaccine antigens with Poly(lactide-co-glycolic acids) (PLGA), an FDA approved biodegradable polymer, has been investigated for targeted M-cell uptake. While PLGA possesses many attractive properties, a successful PLGA based mucosal-targeted vaccine has yet to be introduced. This review focuses on the physiochemical properties important in the preparation of antigen-loaded PLGA microparticles, properties that influence M-cell specific uptake, and the induction of effective immune responses. In addition, a possible role of microparticle properties in immune adjuvant activity is discussed. A careful consideration of these factors may yet lead to the development of an effective needle-free mucosal vaccine using polymer microparticles.

  Keywords: M-cell targeting, PLGA, microparticles
  Affiliation: Division of Biomedical Sciences, University of California, Riverside, CA 92521, USA.
  Key: New Content Free Content Open Access Plus Subscribed Content

Bentham Science Publishers


  Copyright © 1994 - 2015   Bentham Science Publishers