Guest Open Access Plus | Free Content | About | Sign in | New Users: Sign up | Mark List  

CNS & Neurological Disorders - Drug Targets (Formerly Current Drug Targets - CNS & Neurological Disorders)

Volume 7 Issue 2
ISSN: 1871-5273
eISSN: 1996-3181

 

   All Titles

  GABAA Receptors, Anesthetics and Anticonvulsants in Brain Development
  pp.211-224 (14) Authors: Oliver Henschel, Keith E. Gipson, Angelique Bordey
 
 
      Abstract

GABA, acting via GABAA receptors, is well-accepted as the main inhibitory neurotransmitter of the mature brain, where it dampens neuronal excitability. The receptor's properties have been studied extensively, yielding important information about its structure, pharmacology, and regulation that are summarized in this review. Several GABAergic drugs have been commonly used as anesthetics, sedatives, and anticonvulsants for decades. However, findings that GABA has critical functions in brain development, in particular during the late embryonic and neonatal period, raise worthwhile questions regarding the side effects of GABAergic drugs that may lead to long-term cognitive deficits. Here, we will review some of these drugs in parallel with the control of CNS development that GABA exerts via activation of GABAA receptors. This review aims to provide a basic science and clinical perspective on the function of GABA and related pharmaceuticals acting at GABAA receptors.

 
  Keywords: GABA, anesthesia, epilepsy, neurogenesis, glutamate, proliferation, apoptosis, synaptic
  Affiliation: Department of Neurosurgery,Yale University School of Medicine, 333 Cedar Street, FMB 422, New Haven, CT 06520-8082, USA.
 
  Key: New Content Free Content Open Access Plus Subscribed Content

Bentham Science Publishers
www.benthamscience.com

 

  Copyright © 1994 - 2014   Bentham Science Publishers