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CNS & Neurological Disorders - Drug Targets (Formerly Current Drug Targets - CNS & Neurological Disorders)

Volume 10 Issue 3
ISSN: 1871-5273
eISSN: 1996-3181

 

   All Titles

  Prolyl Oligopeptidase, Inositol Phosphate Signalling and Lithium Sensitivity
  pp.333-339 (7) Author: Adrian J. Harwood
 
 
      Abstract

Inhibition of prolyl oligopeptidase (PO) elevates inositol phosphate (IP) signalling and reduces cell sensitivity to lithium (Li+). This review discusses recent evidence that shows PO acts via the multiple inositol polyphosphate phosphatase (MIPP) to regulate gene expression. As a consequence, PO inhibition causes both a transient, rapid increase in I(1,4,5)P3 and a long-term elevation of IP signalling. This pathway is evolutionary conserved, being present in both the social amoeba Dictyostelium and human cell systems, and has potential implications for mental health.

 
  Keywords: Bipolar mood disorder, Dictyostelium, inositol phosphate signalling, lithium, multiple inositol polyphosphate phosphatase, prolyl oligopeptidase, IMPase, LY294002, GSK-3, MIPP, ISYNA1
  Affiliation: School of Biosciences, Cardiff University, Museum Ave, Cardiff, CF10 3AX, UK.
 
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