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Current Organic Synthesis

Volume 6 Issue 1
ISSN: 1570-1794
eISSN: 1875-6271


   All Titles

  Enantioselective Enzyme-Catalysed Synthesis of Cyanohydrins
  pp.15-37 (23) Authors: Jarle Holt, Ulf Hanefeld

Cyanohydrins are valuable intermediates in organic synthesis. They enable an extensive chemistry that can be implemented starting either from the nitrile or from the hydroxy functionality. A number of challenges relevant to the enzyme-catalysed synthesis of chiral cyanohydrins have been addressed in recent years. In this review we will discuss three topics: (1) The enantioselective synthesis of cyanohydrins catalysed by Hydroxynitrile Lyases (Oxynitrilases); (2) The preparation of enantiopure cyanohydrins catalysed by hydrolases/ lipases via (dynamic) kinetic resolutions and (3) the (in situ) conversion of the enantiopure cyanohydrins, extending the use of cyanohydrins as building blocks in organic synthesis.

  Keywords: Cyanohydrin, hydroxynitrile lyase, oxynitrilase, lipase, kinetic resolution, dynamic kinetic resolution
  Affiliation: Gebouw voor Scheikunde, Afdeling Biotechnologie, Technische Universiteit Delft, Julianalaan 136, 2628 BL Delft, The Netherlands.
  Key: New Content Free Content Open Access Plus Subscribed Content

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