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Current Pharmaceutical Biotechnology

Volume 12 Issue 11
ISSN: 1389-2010
eISSN: 1873-4316

 

   All Titles

  Metastasis: Recent Discoveries and Novel Perioperative Treatment Strategies with Particular Interest in the Hemostatic Compound Desmopressin
  pp.1974-1980 (7) Authors: D. F. Alonso, G. V. Ripoll, J. Garona, N. B. Iannucci, D. E. Gomez
 
 
      Abstract

Metastatic disease is responsible for most of cancer lethality. A main obstacle for therapy of advanced cancers is that the outcome of metastasis depends on a complex interplay between malignant and host cells. The perioperative period represents an underutilized window of opportunity for cancer treatment where tumor-host interactions can be modulated, reducing the risk of local recurrences and distant metastases. Blood-saving agents are attractive compounds to be administered during tumor surgery. Desmopressin (DDAVP) is a safe and convenient hemostatic peptide with proved antimetastastic properties in experimental models and veterinary clinical trials. The compound seems to induce a dual angiostatic and antimetastatic effect, breaking the cooperative function of cancer cells and endothelial cells during residual tumor progression. DDAVP is therefore an interesting lead compound to develop novel synthetic peptide analogs with enhanced antitumor properties.

 
  Keywords: Angiogenesis, breast cancer, desmopressin, hemostasis, Surgery, tumor spread, vasopressin analog, cancer lethality, hemostatic peptide, veterinary clinical trials, synthetic peptide analogs, blood vessels, occult neoplastic cells, colonic stents, preclinical models
  Affiliation: Laboratorio de Oncologia Molecular, Universidad Nacional de Quilmes, R. Saenz Pena 352, Bernal B1876 Buenos Aires, Argentina.
 
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