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Current Pharmaceutical Design

Volume 9 Issue 16
ISSN: 1381-6128
eISSN: 1873-4286

 

   All Titles

  Biogenic Peptides and Their Potential Use
  pp.1345-1355 (11) Authors: Naoyuki Yamamoto, Masahiro Ejiri, Seiichi Mizuno
 
 
      Abstract

This paper reviews bioactive peptides, biogenic peptides, opioid peptides, immunostimulating peptides, mineral soluble peptides, antihypertensive peptides and antimicrobial peptides originating from food materials and enzymatic hydrolysis of proteins. Antihypertensive peptides are extensively reviewed and have been divided into angiotensin Iconverting enzyme inhibitory peptides and others. These peptides are produced in the enzymatic hydrolysate of treated food materials such as milk, animal and fish meat, maize, wheat, soybeans and egg, and also from microbe-fermented products. Peptides with strong antihypertensive effects on spontaneously hypertensive rats are discussed and are divided into high and low angiotensin Iconverting enzyme inhibitory activities. In addition, new topics from our studies on antihypertensive peptides are introduced. Efficacies of these peptides in clinical studies and differences with medicinal substances are summarized. Recent studies in this area shown the possibility of using biogenic peptides for improvements in treatment or prevention of hypertension.

 
  Keywords: angiotensin I-converting enzyme, aceI peptide, spontaneously hypertensive rats, concentration of peptide showing, inhibition of ace activity
  Affiliation: R&D center, Calpis Co., Ltd., 11-10, 5-Chome, Fuchinobe, Sagamihara, Kanagawa 229 Japan.
 
  Key: New Content Free Content Open Access Plus Subscribed Content

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