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Current Pharmaceutical Design

Volume 14 Issue 23
ISSN: 1381-6128
eISSN: 1873-4286

 

   All Titles

  The Endocannabinoid System in Peripheral Lymphocytes as a Mirror of Neuroinflammatory Diseases
  pp.2370-2382 (13) Authors: Diego Centonze, Luca Battistini, Mauro Maccarrone
 
 
      Abstract

During immuno-mediated attack of the brain, activation of endocannabinoids represents a protective mechanism, aimed at reducing both neurodegenerative and inflammatory damage through various and partially converging mechanisms that involve neuronal and immune cells. Here, we review the main alterations of the endocannabinoid system (ECS) within the central nervous system and in peripheral blood mononuclear cells, in order to discuss the intriguing observation that elements of the peripheral ECS mirror central dysfunctions of endocannabinoid signaling. As a consequence, elements of blood ECS might serve as novel, non-invasive diagnostic tools of several neurological disorders, and targeting the ECS might be useful for therapeutic purposes. In addition, we discuss the appealing working hypothesis that the presence of type-1 cannabinoid receptors on the luminal side, and that of type-2 cannabinoid receptors on the abluminal side of the blood-brain barrier, could drive a unidirectional transport of AEA in the luminal → abluminal direction (i.e., from blood to brain), thus implying that blood may be a reservoir of AEA for the brain. On this basis, it can be expected that an unbalance of the endogenous tone of AEA in the blood may sustain a similar unbalance of its level within the brain, as demonstrated in Huntington's disease, Parkinson's disease, multiple sclerosis, attention-deficit/hyperactivity disorder, schizophrenia, depression and headache.

 
  Keywords: blood-brain barrier, cannabinoid receptors, depression, immune response, lymphocytes, metabolism, migraine, neurodegeneration, neuroinflammation, transport, vanilloid receptor
  Affiliation: Department of Biomedical Sciences, University of Teramo, Piazza A. Moro 45, 64100 Teramo, Italy.
 
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