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Current Pharmaceutical Design

Volume 15 Issue 28
ISSN: 1381-6128
eISSN: 1873-4286

 

   All Titles

  Prediction of MHC-Peptide Binding: A Systematic and Comprehensive Overview
  pp.3209-3220 (12) Authors: Esther M. Lafuente, Pedro A. Reche
 
 
      Abstract

T cell immune responses are driven by the recognition of peptide antigens (T cell epitopes) that are bound to major histocompatibility complex (MHC) molecules. T cell epitope immunogenicity is thus contingent on several events, including appropriate and effective processing of the peptide from its protein source, stable peptide binding to the MHC molecule, and recognition of the MHC-bound peptide by the T cell receptor. Of these three hallmarks, MHC-peptide binding is the most selective event that determines T cell epitopes. Therefore, prediction of MHC-peptide binding constitutes the principal basis for anticipating potential T cell epitopes. The tremendous relevance of epitope identification in vaccine design and in the monitoring of T cell responses has spurred the development of many computational methods for predicting MHC-peptide binding that improve the efficiency and economics of T cell epitope identification. In this report, we will systematically examine the available methods for predicting MHC-peptide binding and discuss their most relevant advantages and drawbacks.

 
  Keywords: Peptide, T cells, epitopes, MHC, HLA, prediction
  Affiliation: Department of Immunology, Facultad de Medicina, Universidad Complutense de Madrid, Ave. Complutense s/n, Madrid 28040, Spain.
 
  Key: New Content Free Content Open Access Plus Subscribed Content

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