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Current Protein & Peptide Science

Volume 13 Issue 5
ISSN: 1389-2037
eISSN: 1875-5550

 

   All Titles

  SUMOylation in Control of Accurate Chromosome Segregation during Mitosis
  pp.467-481 (15) Authors: Jun Wan, Divya Subramonian, Xiang-Dong Zhang
 
 
      Abstract

Posttranslational protein modification by small ubiquitin-related modifier (SUMO) has emerged as an important regulatory mechanism for chromosome segregation during mitosis. This review focuses on how SUMOylation regulates the centromere and kinetochore activities to achieve accurate chromosome segregation during mitosis. Kinetochores are assembled on the specialized chromatin domains called centromeres and serve as the sites for attaching spindle microtubule to segregate sister chromatids to daughter cells. Many proteins associated with mitotic centromeres and kinetochores have been recently found to be modified by SUMO. Although we are still at the early stage of elucidating how SUMOylation controls chromosome segregation during mitosis, a substantial progress has been achieved over the past decade. Furthermore, a major theme that has emerged from the recent studies of SUMOylation in mitosis is that both SUMO conjugation and deconjugation are critical for kinetochore assembly and disassembly. Lastly, we propose a model that SUMOylation coordinates multiple centromere and kinetochore activities to ensure accurate chromosome segregation.

 
  Keywords: Centromere, chromosome segregation, fibrous corona, kinetochore, mitosis, SUMOylation, SUMO interacting motif (SIM), spindle assembly checkpoint (SAC)
  Affiliation: Department of Biological Sciences, 5047 Gullen Mall, Wayne State University, Detroit, Michigan 48202, USA.
 
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