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Current Protein & Peptide Science

Volume 13 Issue 8
ISSN: 1389-2037
eISSN: 1875-5550

 

   All Titles

  The Role of Cysteine Proteinases and their Inhibitors in the Host-Pathogen Cross Talk
  pp.767-775 (9) Author: Natasa Kopitar-Jerala
 
 
      Abstract

Proteinases and their inhibitors play essential functional roles in basic biological processes in both hosts and pathogens. Endo/lysosomal cathepsins participate in immune response in pathogen recognition and elimination. They are essential for both antigen processing and presentation (host adaptive immune response) and activation of endosomal Toll like receptors (innate immune response). Pathogens can produce proteases and also natural inhibitors to subvert the host immune response. Several pathogens are sensed through the intracellular pathogen recognition receptors, but only some of them use the host proteolytic system to escape into the cytosol. In this review, I provide an update on the most recent developments regarding the role of proteinases and their inhibitors in the initiation and regulation of immune responses.

 
  Keywords: Bacteria, immune response, protease/cysteine proteinase, proteinase inhibitor, virus, Cysteine Cathepsins, Endogenous Protein Inhibitors, Dendritic Cells, CMKLR1, C-terminus
  Affiliation: Department of Biochemistry, Molecular and Structural Biology, ›Jozef Stefan‹ Institute, Jamova 39, 1000 Ljubljana, Slovenia.
 
  Key: New Content Free Content Open Access Plus Subscribed Content

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