Guest Open Access Plus | Free Content | About | Sign in | New Users: Sign up | Mark List  

Current Protein & Peptide Science

Volume 13 Issue 8
ISSN: 1389-2037
eISSN: 1875-5550

 

   All Titles

  Protein-Carbohydrate Interactions Studied by NMR: From Molecular Recognition to Drug Design
  pp.816-830 (15) Authors: Maria del Carmen Fernandez-Alonso, Dolores Diaz, Manuel Alvaro Berbis, Filipa Marcelo, Javier Canada, Jesus Jimenez-Barbero
 
 
      Abstract

Diseases that result from infection are, in general, a consequence of specific interactions between a pathogenic organism and the cells. The study of host-pathogen interactions has provided insights for the design of drugs with therapeutic properties. One area that has proved to be promising for such studies is the constituted by carbohydrates which participate in biological processes of paramount importance. On the one hand, carbohydrates have shown to be information carriers with similar, if not higher, importance than traditionally considered carriers as amino acids and nucleic acids. On the other hand, the knowledge on molecular recognition of sugars by lectins and other carbohydrate-binding proteins has been employed for the development of new biomedical strategies. Biophysical techniques such as X-Ray crystallography and NMR spectroscopy lead currently the investigation on this field. In this review, a description of traditional and novel NMR methodologies employed in the study of sugar-protein interactions is briefly presented in combination with a palette of NMR-based studies related to biologically and/or pharmaceutically relevant applications.

 
  Keywords: NMR, molecular modeling, protein-ligand interactions, drug targeting, Carbohydrate-Protein Interaction, Apolar Interactions, Hydrogen Bonding, PROTEIN-CARBOHYDRATE INTERACTIONS, Distortion of Sugar Rings, Isotope Labeling
  Affiliation: Centro de Investigaciones Biologicas-CSIC. Calle Ramiro de Maeztu, 9. 28040. Madrid, Spain.
 
  Key: New Content Free Content Open Access Plus Subscribed Content

Bentham Science Publishers
www.benthamscience.com

 

  Copyright © 1994 - 2014   Bentham Science Publishers