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Current Radiopharmaceuticals

Volume 1 Issue 2
ISSN: 1874-4710
eISSN: 1874-4729

 

   All Titles

  Synthesis of 1-Amino-2-[3-13C]propanol Hydrochloride: Completion of Synthetic Methods for all of its 13C- and 15N-Isotopomers
  pp.120-121 (2) Authors: K. Iida, Y. Nakajima, M. Kajiwara
doi: 10.2174/1874471010801020120
 
 
      Abstract

1-Amino-2-[3-13C]propanol hydrochloride (1) was synthesized by the coupling reaction of 2-phthalimidoacetyl chloride (2) with [13C]methylmagnesium iodide in the presence of copper iodide, followed by reduction with sodium borohydride and hydrolysis, in 64 % total yield from the 13C-source. All 13C- and 15N-isotopomers of 1-amino-2-propanol are now obtainable by using appropriate combinations of 13C-labeled sodium acetate, 13C- and/or 15N-labeled glycine, and potassium [15N]phthalimide.

 
  Keywords: 13C-labeling synthesis, 1-amino-2-[3-13C]propanol, iodo[13C]methane, 13C, 15N-isotopomer, vitamin B12, biosynthetic intermediate
  Affiliation: Department of Medicinal Chemistry,Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose-shi, Tokyo 204-8588, Japan.
 
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