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Current Signal Transduction Therapy

Volume 7 Issue 2
ISSN: 1574-3624


   All Titles

  Update on the Pathophysiological Role of Intracellular Signaling Pathways in Atherosclerotic Plaques and Ischemic Myocardium
  pp.104-110 (7) Authors: Fabrizio Montecucco, Vincent Braunersreuther, Giorgio Luciano Viviani, Sebastien Lenglet, Francois Mach

Acute atherosclerotic complications, such as myocardial infarction, are often provoked by the rupture of an atherosclerotic plaque and the subsequent thrombotic occlusion of the arterial lumen, which interrupts the blood flow and renders ischemic the downstream peripheral tissue. Several inflammatory mediators (including cytokines, chemokines and matrix metalloproteases) have been shown to orchestrate common pathophysiological mechanisms regulating both plaque vulnerability and myocardial injury. In particular, the selective activation of certain protective intracellular signaling pathways might represent a promising target to reduce the dramatic consequences of an ischemic cardiac event. In the present review we will update evidence on the active role of intracellular kinase cascades (such as mitogen-activated protein kinases [MAPKs], Akt, Janus kinase [JAK]-signal transducer and activator of transcription [STAT]) to reduce the global patient vulnerability for acute myocardial infarction.

  Keywords: Kinases, plaque vulnerability, leukocytes, Signaling Pathways, Atherosclerotic Plaques, Ischemic Myocardium, myocardial infarction, inflammatory mediators, STAT, MAPKs
  Affiliation: Avenue de la Roseraie 64, Division of Cardiology, Foundation for Medical Researches, University of Geneva, Avenue de la Roseraie 64, 1211 Geneva, Switzerland.
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