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Recent Patents on Drug Delivery & Formulation

Volume 6 Issue 2
ISSN: 1872-2113
eISSN: 2212-4039

 

   All Titles

  Thermal Inkjet Printing in Tissue Engineering and Regenerative Medicine
  pp.149-155 (7) Authors: Xiaofeng Cui, Thomas Boland, Darryl D.D'Lima, Martin K. Lotz
 
 
      Abstract

With the advantages of high throughput, digital control, and highly accurate placement of cells and biomaterial scaffold to the desired 2D and 3D locations, bioprinting has great potential to develop promising approaches in translational medicine and organ replacement. The most recent advances in organ and tissue bioprinting based on the thermal inkjet printing technology are described in this review. Bioprinting has no or little side effect to the printed mammalian cells and it can conveniently combine with gene transfection or drug delivery to the ejected living systems during the precise placement for tissue construction. With layer-by-layer assembly, 3D tissues with complex structures can be printed using scanned CT or MRI images. Vascular or nerve systems can be enabled simultaneously during the organ construction with digital control. Therefore, bioprinting is the only solution to solve this critical issue in thick and complex tissues fabrication with vascular system. Collectively, bioprinting based on thermal inkjet has great potential and broad applications in tissue engineering and regenerative medicine. This review article introduces some important patents related to bioprinting of living systems and the applications of bioprinting in tissue engineering field.

 
  Keywords: Gene transfection, growth factor, hydrogel, inkjet printing, microvasculature, photopolymerization, tissue engineering, CARTILAGE REPAIR, HUMAN MICROVASCULATURE FABRICATION
  Affiliation: Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
 
  Key: New Content Free Content Open Access Plus Subscribed Content

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