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Drug Delivery Letters

Volume 1 Issue 2
ISSN: 2210-304x
eISSN: 2210-3031

 

   All Titles

  Recent Advances Using Supercritical Fluid Techniques for Pulmonary Administration of Macromolecules via Dry Powder Formulations
  pp.128-134 (7) Authors: Iman M. Al-fagih, Fars K. Alanazi, Gillian A. Hutcheon, Imran Y. Saleem
doi: 10.2174/2210304X11101020128
 
 
      Abstract

Growing demands on a suitable formulation method that ensures the stability of the active compound coupled with the limitations of current methods (milling, lyophilization, spray drying, and freeze spray drying) has brought wide attention to supercritical fluid (SCF) technology. Advantages of using the SCF technology comprise its high abilities, adaptability in providing alternative processing methods, high compressibility and diffusivity of the supercritical fluid, capability as an alternative for conventional organic solvents, and the option to attain different processing parameters which would be otherwise difficult to conduct with traditional methods. This review proposes to present an up-to-date outlook on dry powder pulmonary formulations of macromolecules using SCF technology.

 
  Keywords: Dry powder, super critical fluid, protein, microparticles, peptide, macromolecules, SCF, Anaemia, Encapsulation of Insulin, POWDER INHALATION, inhalation
  Affiliation: School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, James Parson Building, Byrom Street, Liverpool, L3 3AF UK.
 
  Key: New Content Free Content Open Access Plus Subscribed Content

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