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Drug Metabolism Letters

Volume 2 Issue 1
ISSN: 1872-3128
eISSN: 1874-0758


   All Titles

  Investigations Into the Drug-Drug Interaction Potential of Tapentadol in Human Liver Microsomes and Fresh Human Hepatocytes
  pp.67-75 (9) Authors: Christa Kneip, Rolf Terlinden, Horst Beier, Genfu Chen

The new analgesic tapentadol was evaluated for induction and inhibition of several cytochrome P450 enzymes in vitro, and protein binding was assessed. It was concluded that no clinically relevant drug drug interactions are likely to occur through either mechanism.

  Keywords: protein binding, CYP isoforms, Hepatocytes, omeprazole, glucuronidation
  Affiliation: Grunenthal GmbH 52078 Aachen,Germany.
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