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Investigations Into the Drug-Drug Interaction Potential of Tapentadol in Human Liver Microsomes and Fresh Human Hepatocytes
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pp.67-75 (9) Authors: Christa Kneip, Rolf Terlinden, Horst Beier, Genfu Chen
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| Abstract |
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The new analgesic tapentadol was evaluated for induction and inhibition of several cytochrome P450 enzymes in vitro, and protein binding was assessed. It was concluded that no clinically relevant drug – drug interactions are likely to occur through either mechanism.
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Keywords:
protein binding, CYP isoforms, Hepatocytes, omeprazole, glucuronidation
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Affiliation:
Grunenthal GmbH 52078 Aachen,Germany.
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