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Drug Metabolism Letters

Volume 2 Issue 2
ISSN: 1872-3128
eISSN: 1874-0758

 

   All Titles

  Long Term Treatment with Tetradecylthioacetic Acid Improves the Antioxidant Status in Obese Zucker (fa/fa) Rats
  pp.138-145 (8) Authors: Hege Wergedahl, Kjetil Berge, Pavol Bohov, Karl-Johan Tronstad, Lise Madsen, Rolf K. Berge
 
 
      Abstract

Increased oxidative stress was observed in obese Zucker rats. Treatment of obese rats with tetradecylthioacetic acid for 12 weeks increased the H2O2-production, but decreased plasma malondialdehyde, changed the serum fatty acid profile, increased liver fatty acid binding protein mRNA, and lowered serum insulin, thereby enhancing the antioxidant defense system.

 
  Keywords: Obesity, peroxisome proliferation, antioxidant enzymes, hydrogen peroxide, α-tocopherol, malondialdehyde
  Affiliation: Institute of Medicine, Section of Medical Biochemistry, University of Bergen, Haukeland University Hospital,N-5021 Bergen, Norway.
 
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