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Recent Patents on Endocrine, Metabolic & Immune Drug Discovery

Volume 5 Issue 2
ISSN: 1872-2148
eISSN: 2212-3334

 

   All Titles

  Fetuin-A: A Multifunctional Protein
  pp.124-146 (23) Authors: Katsuhito Mori, Masanori Emoto, Masaaki Inaba
 
 
      Abstract

Sixty-six years have elapsed since the discovery of fetuin in 1944, but its importance in mammalian physiology has only recently been appreciated. Fetuin, first isolated from fetal bovine serum and now most commonly known as either fetuin-A, alpha-2-HS-glycoprotein (recommended name by UniprotKB and PIR), or α2-Heremans-Schmid glycoprotein, functions as an important component of diverse normal and pathological processes, including vascular calcification and bone metabolism regulation, insulin resistance, protease activity control, keratinocytes migration, and breast tumor cell proliferative signaling. Fetuin-A has also been identified as a biomarker for neurodegenerative disease. Here, we summarize recent publications focusing on the structural and functional properties of fetuin-A. The emerging importance of fetuin-A for both diagnosis and therapeutics has come to the attention of the pharmaceutical industry. Therefore, we will discuss the status of patents based on fetuin-A.

 
  Keywords: AHSG, atherosclerosis, bone metabolism, diabetes, fetuin-A, insulin resistance, vascular calcification, multiple sclerosis, Multifunctional Protein, TGF-b
  Affiliation: Metabolism, Endocrinology and Molecular Medicine Osaka City University Graduate School of Medicine 1-4-3, Asahi-machi, Abeno-ku, Osaka 545-8585, Japan.
 
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