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Inflammation & Allergy-Drug Targets (Formerly Current Drug Targets - Inflammation & Allergy)

Volume 7 Issue 1
ISSN: 1871-5281
eISSN: 2212-4055

 

   All Titles

  Transferrin and the Transferrin Receptor: Of Magic Bullets and Other Concerns
  pp.41-52 (12) Authors: Maria F. Macedo, Maria de Sousa
 
 
      Abstract

Transferrin (Trf) is a highly conserved serum glycoprotein mostly known for its iron transport capacity. As iron is an indispensable nutrient for cell division, Trf and its receptor have long been used as targets of pharmacological intervention mostly for cancer therapy and for diagnosis in inflammation. In recent years several independent pieces of work including data from our group, indicated that Trf can also have an iron independent role in the immune system. In this article new emerging roles of Trf and its receptor on iron independent processes and in drug delivery are reviewed.

 
  Keywords: Transferrin, transferrin receptor, immunology, inflammation, drug targets, blood brain barrier, cancer
  Affiliation: IRIS, IBMC, Rua do Campo Alegre 823, 4150-180 Porto, Portugal.
 
  Key: New Content Free Content Open Access Plus Subscribed Content

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