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Infectious Disorders - Drug Targets (Formerly Current Drug Targets - Infectious Disorders)

Volume 7 Issue 2
ISSN: 1871-5265
eISSN: 2212-3989

 

   All Titles

  Drug Targets in Mycobacterial Sulfur Metabolism
  pp.140-158 (19) Authors: Devayani P. Bhave, Wilson B. Muse III, Kate S. Carroll
 
 
      Abstract

The identification of new antibacterial targets is urgently needed to address multidrug resistant and latent tuberculosis infection. Sulfur metabolic pathways are essential for survival and the expression of virulence in many pathogenic bacteria, including Mycobacterium tuberculosis. In addition, microbial sulfur metabolic pathways are largely absent in humans and therefore, represent unique targets for therapeutic intervention. In this review, we summarize our current understanding of the enzymes associated with the production of sulfated and reduced sulfur-containing metabolites in Mycobacteria. Small molecule inhibitors of these catalysts represent valuable chemical tools that can be used to investigate the role of sulfur metabolism throughout the Mycobacterial lifecycle and may also represent new leads for drug development. In this light, we also summarize recent progress in the development of inhibitors of sulfur metabolism enzymes.

 
  Keywords: Tuberculosis, mycobacteria, sulfur metabolism, enzymes, thiols, sulfation, drug design, inhibitors
  Affiliation: University of Michigan, Life Sciences Institute, 210 Washtenaw Ave., Ann Arbor, MI, 48109-2216.
 
  Key: New Content Free Content Open Access Plus Subscribed Content

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