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Letters in Drug Design & Discovery

Volume 5 Issue 2
ISSN: 1570-1808
eISSN: 1875-628X


   All Titles

  Phenylpyazoleanilides as a Potent Inhibitor of IL-15 Dependent T Cell Proliferation. Part 1: A New Class of Orally Available Immunomodulators
  pp.111-115 (5) Authors: Hiroyuki Ushio, Seigo Ishibuchi, Kunitomo Adachi, Kouichi Oshita, Kenji Chiba

In research for a new immunomodulator, we discoverd a novel hydroxypiperidine derivative 9h which was a potent inhibitor of IL-15induced T cell activation. Further modification of 9h gave a potent and orally active agent 10 which was effective in a mouse CIA model.

  Keywords: Phenylpyrazoleanilide, IL-15, Prodrug, CIA
  Affiliation: Medicinal Chemistry Laboratory,Research division, Mitsubishi Tanabe Pharma Corporation, 1000,Kamoshida-cho, Aoba-ku, Yokohama 227-0033, Japan.
  Key: New Content Free Content Open Access Plus Subscribed Content

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