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Letters in Drug Design & Discovery

Volume 5 Issue 4
ISSN: 1570-1808
eISSN: 1875-628X

 

   All Titles

  Phenylpyazoleanilides as Potent Inhibitor of IL-15 Dependent T Cell Proliferation. Part 2: Discovery of a New Drug Candidate, Y-320
  pp.292-296 (5) Authors: Hiroyuki Ushio, Seigo Ishibuchi, Kunitomo Adachi, Kouichi Oshita, Kenji Chiba
 
 
      Abstract

Through the optimization of the active metabolite 2 of the piperidine derivative 1, we discovered a potent new drug candidate for the treatment of RA, Y-320 that inhibits T cell activation induced by IL-15 and shows a therapeutic effect on collagen-induced arthritis in DBA/1J mice. Design and structure-activity relationships are described.

 
  Keywords: Y-320, IL-15, Phenylpyrazoleanilide, RA, CIA
  Affiliation: Medicinal Chemistry Laboratory,Research division, Mitsubishi Tanabe Pharma Corporation, 1000, Kamoshida-cho, Aoba-ku, Yokohama 227-0033, Japan.
 
  Key: New Content Free Content Open Access Plus Subscribed Content

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