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Discovery of AX8312, an N-alkyl-Gly-boro-Pro Derivative that Accelerates Recovery from Neutropenia in the Mouse
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pp.340-345 (6) Authors: Emme C.K. Lin, Kevin R. Shreder, Melissa C. Zhang, Yi Hu, Lisa Morera, Min Wu, Melissa S. Wong, Lifu Ma, Doris Chun, Sergio Corral, John W. Kozarich
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| Abstract |
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A screen of N-alkyl-Gly-boro-Pro DPP inhibitors using an acute murine model revealed that N-adamantyl and N-cycloalkyl groups greater in size than cyclobutyl significantly induced G-CSF. Treatment of neutropenic mice with the most efficacious compound, AX8312 (N-(1-adamantyl)-Gly-boro-Pro), resulted in a faster and greater neutrophil recovery versus vehicle-treated mice. |
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Keywords:
N-alkyl-Gly-boro-Pro, G-CSF, Neutropenia, Cytokine, AX8312 |
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Affiliation:
ActivX Biosciences, Inc., 11025 N. Torrey Pines Road, La Jolla, CA 92037, USA. |
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