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Short Synthesis of the Selective Rho-Kinase Inhibitor Y-27632 and of Its Enantiomer
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pp.634-636 (3) Authors: D. Belotti, J. L. Peglion, J. Cossy
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| Abstract |
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Y-27632 and its enantiomer were synthesized in 8 steps from trans-1,4-cyclohexanedicarboxylic acid by using a diastereoselective reductive amination of a ketone. |
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Keywords:
kinase inhibitor, rho-associated kinase, reductive amination |
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Affiliation:
Laboratoire de ChimieOrganique associe au CNRS, ESPCI, 10 rue Vauquelin, 75231 Paris Cedex05, France. |
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