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Recent Advances Towards New Anti-Infective Agents that Inhibit Cell Surface Protein Anchoring in Staphylococcus aureus and Other Gram-Positive Pathogens
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pp.991-1000 (10) Authors: N. Suree, M. E. Jung, R. T. Clubb
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| Abstract |
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Sortase enzymes are attractive targets for the development of new anti-infective agents against Gram-positive pathogens because they covalently anchor virulence factors to the cell wall. Here we review what is known about the mechanism of sortase mediated protein anchoring and discuss recently identified inhibitors of this new important enzyme family. |
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Keywords:
Sortase, antibiotic, anti-infective, Staphylococcus aureus, gram-positive bacteria, inhibitor, SrtA |
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Affiliation:
Department of Chemistry&Biochemistry, University of California, Los Angeles, 405 Hilgard Avenue,Los Angeles, CA 90095-1570, USA. |
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