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Mini-Reviews in Organic Chemistry

Volume 4 Issue 4
ISSN: 1570-193X
eISSN: 1875-6298

 

   All Titles

  Recent Developments and Trends in 18F-Radiochemistry: Syntheses and Applications
  pp.317-329 (13) Authors: Ralf Schirrmacher, Carmen Wangler, Esther Schirrmacher
 
 
      Abstract

In this short review we describe recent methods and novel trends for the introduction of fluorine-18 into molecules which in turn are intended to serve as imaging agents for the in vivo imaging modality positron emission tomography (PET). These 18F-labeling schemes are based on enzymatic fluorination, the use of ionic liquids, protic solvents acting as catalysts, application of “click chemistry”, thiol-reactive labeling agents for peptide and protein labeling and the most recent introduction of “non-classical” radiochemistry based on organo-phosphorous, organo-boron and organo-silicon radiochemistry. The latter approach for the first time introduced an 18F-chemistry characterized by high selectivity and unique efficiency making complicated work-up procedures obsolete.

 
  Keywords: Fluorine-18, positron emission tomography (PET), labeling chemistry
  Affiliation: Montreal Neurological Institute, McGill University, Montreal, Canada.
 
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