All
Titles
|
| |
Design and Synthesis of Substrates for Model Ribosomal Reactions
|
| |
pp.392-401 (10) Authors: Stanislav G. Bayryamov, Nikolay G. Vassilev, Miroslav A. Rangelov, Aneta P. Mladjova, Dimiter D. Petkov
|
|
| |
|
| Abstract |
| |
2'/3'-O-[Bz(NO2)-Orn(Boc)]-5'-O-Piv-Ado (1) and its deoxy analog: 3'-O-[Bz(NO2)-Orn(Boc)]-5'-O-Piv-2'- dAdo (2) were designed and synthesized as substrates for the model ribosome reaction we used to demonstrate the crucial role of A76 2'-OH of peptidyl-tRNA in the rate acceleration of peptide bond formation during protein biosynthesis. |
|
| |
Keywords:
Design, peptide synthesis, nucleoside synthesis, ribosome catalysis |
| |
Affiliation:
Laboratory of BioCatalysis, Institute of Organic Chemistry, Bulgrian Academy of Sciences, Acad. Bonchev Str., bld. 9, 1113 Sofia, Bulgaria. |
| |
|
|
