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Recent Patents on Catalysis

Volume 1 Issue 2
ISSN: 2211-548X
eISSN: 2211-5498


   All Titles

  Synthesis of Dihydropyridines: Patented Catalysts and Biological Applications
  pp.119-128 (10) Authors: Laura M. Sanchez, Angel G. Sathicq, Horacio J. Thomas, Gustavo P. Romanelli
doi: 10.2174/2211548X11201020119

The present review focuses on the patented synthetic methods and numerous pharmaceutical applications of 1,4-dihydropyridines. They were originally prepared by the Hantzsch multicomponent reaction, but nowadays there are several new methods. They have improved reaction yield and have reduced the risks of contaminating the environment. These improvements were achieved through the use of different catalytic systems, a variety of reaction solvents, and also some reactions were carried out without either catalyst or reaction solvent.

  Keywords: Biological applications, dihydropyridines, Hantzsch reaction, patented catalysts
  Affiliation: Centro de Investigacion y Desarrollo en Ciencias Aplicadas “Dr. J. J. Ronco” (CINDECA), Departamento de Quimica, Facultad de Ciencias Exactas, UNLP-CCT-CONICET. Calles 47 N° 257, B1900AJK La Plata, Argentina.
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